Is IVF Really Painful? Everything You Need to Know About IVF Pain

IVF can be a challenging process, both physically and emotionally. It involves several stages, including ovarian stimulation, egg retrieval, fertilisation, and embryo transfer, each with its own potential difficulties. Understanding these stages can help you better manage any physical discomfort and emotional stress. The pain experienced during IVF differs from that of pregnancy, so it’s important to focus on managing both the physical symptoms and emotional well-being.

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Starting IVF is a big decision, and it’s completely natural to feel concerned about the physical discomfort. Pain is often a common concern, you might wonder how intense it will be, which steps might be most uncomfortable, and how it compares to a natural pregnancy.



Pain affects everyone differently, and each stage of IVF, from hormonal injections to egg collection and embryo transfer, comes with its own unique challenges. It’s helpful to learn what to expect and how you can manage these sensations. You can also take steps to minimise pain and manage any stress, helping you feel more in control throughout the process.


In-Vitro Fertilisation (IVF): An Overview

IVF is a widely used treatment for infertility, involving the stimulation of your ovaries to produce eggs, retrieving them, fertilising them in a lab, and transferring embryos into your uterus.

It may be recommended for conditions like blocked fallopian tubes, male infertility, ovarian failure, endometriosis, or unexplained infertility. While IVF has provided many with hope, it’s natural to feel concerned about the pain it may involve.

The level of pain you experience during IVF might vary, as everyone’s tolerance to discomfort is different. Most people find the pain manageable. Your experience might depend on your sensitivity to hormones, the procedures, and your personal pain threshold. Understanding what to expect can help you feel more prepared and at ease during the process.


IVF Procedure

IVF involves a number of steps, each of which has the potential to be painful or uncomfortable. The following is a step-by-step account to attempt to give some idea of what to expect:

Ovarian stimulation

During IVF, hormone injections are used to stimulate your ovaries to produce multiple follicles containing eggs. You’ll receive daily injections of gonadotropins (recombinant FSH and LH), along with regular blood tests and ultrasound scans to monitor your response to the treatment.

  • Injection site reactions: Redness, bruising, or a stinging sensation at the point where the needle goes into the skin, and these disappear in a few days or hours.
  • Abdominal bloating and pressure: Enlargement of your ovaries caused by the medication can also cause you to experience tightness, bloating, or cramps similar to severe menstrual cramps.
  • Ovarian Hyperstimulation Syndrome (OHSS): Mild to moderate OHSS is fairly common, while severe cases are rare. It might cause symptoms like abdominal pain, nausea, and fluid retention. Your healthcare professional monitors your response to the hormones very closely in an effort to prevent or treat it.
  • Mood swings and fatigue: Rising hormone levels induce mood swings, fatigue, and, at times, headaches.

This may be uncomfortable if you are sensitive to injections or experience hormonal fluctuations. However, your healthcare expert can offer support and advice on managing any side effects.


Egg retrieval

Once your follicles have matured, preparation for the egg collection procedure is arranged. This procedure is typically performed under light anaesthesia or sedation 36 hours after receiving the trigger injection.


During the procedure, you might be anaesthetised, and pain is uncommon at the time of the procedure. The eggs are retrieved using a fine needle inserted through the vaginal wall. Following the procedure, Cramping, spotting, or bleeding can occur after the anaesthesia has elapsed, and these usually last for a few days.


Potential risks include harm to surrounding structures, internal haemorrhage, or infection of the pelvic cavity. If you experience severe pain, fever, or strange signs, seek emergency consultation from your healthcare expert. Resting adequately following this and having someone accompany you can simplify your recovery.


Egg fertilisation

Your eggs are fertilised in a lab, where your partner's or donor sperm is mixed with the eggs. If needed, intracytoplasmic sperm injection (ICSI) can be done, in which one sperm is injected directly into an egg. As you are not directly involved in this process, you will not feel anything.


While not physically painful, this stage can be emotionally challenging as you wait for confirmation of successful fertilisation.


Embryo transfer

Following fertilisation, one or more embryos are inserted into your uterus a few days later. It is quick and less painful, and only takes a few minutes. It is similar to a cervical smear test.


There may be pain like:


  • Mild cramping: There may be a dull, short-lived pain when the catheter passes through the cervix during transfer.
  • Spotting: There might be a bit of blood afterwards. This is typically minimal and might clear in a day or two.
  • Emotional stress: The two-week wait for the pregnancy test is often the most stressful part of the process, typically resulting in heightened anxiety or anticipation.

Knowing the IVF process, you are able to deal with pain and emotional issues more effectively. Along the way, having clear communication with your healthcare professional might help you relax and be comfortable.


Is IVF a Painful Experience?

IVF is usually not linked to acute or intolerable pain, but it comes with multiple degrees of physical and emotional distress. The discomfort associated with IVF is usually mild and temporary, though some individuals may experience varying levels of pain.

The most difficult parts are typically the hormonal injections, the egg retrieval process, and the emotional stress. Pain sensitivity does differ, though, so while some are uncomfortable with the steps, others won't experience much discomfort at all.


How does IVF pain compare to natural conception?

Comparing pain from IVF to pregnancy-induced pain, they are pretty different in duration as well as severity. IVF-related discomfort is typically temporary and confined to specific stages, such as the stimulation injections or egg retrieval, and is generally less severe.


Pregnancy can bring various discomforts, including morning sickness, pelvic girdle pain, and the intense pain of contractions during labour.

  • IVF Pain: Much of the pain from IVF is temporary and related to injections or procedures such as egg retrieval. The pain tends to be less severe and can be treated with over-the-counter pain medication or rest. The pain generally subsides once the procedure is complete, and there are no long-term physical symptoms to deal with.
  • Pregnancy Pain: Pregnancy entails more extended pain, such as the enlargement of the uterus, which might cause pain and discomfort, like backache or stretching of ligaments. Throughout pregnancy, most individuals endure a lot of discomfort, especially during the final stages, with labour pain being extremely severe and protracted.

Types of Pain You May Experience During IVF

  • Physical Pain: You could experience bruising or tenderness at injection areas, cramps in the abdomen, bloating, and pain after egg retrieval. These might be minimal and resolved in a few days.
  • Emotional Distress: IVF is emotionally stressful. Anxiety, fear of failure, irritability, and mental exhaustion can all play a role in how you feel physical pain. The emotional stress is usually increased by the uncertainty of the process and the lengthy period of time between procedures.

Managing Pain During IVF

Initiating an IVF journey can be filled with many unknowns, many of which may also involve physical and emotional challenges. Having a sense of how to manage physical discomfort and emotional upset during the IVF journey is key so that you may maintain your health throughout the process.


While IVF discomfort may not be typically extreme, learning to manage pain effectively can help you feel more self-assured and increase your overall experience.

Managing physical pain during IVF

IVF involves physical distress and strain, but with appropriate management techniques, you can successfully overcome these symptoms.


  • Hormonal injections: Hormonal injections to trigger your ovaries can cause aching at the injection sites, bruising, redness, or stinging. To avoid bruising, rotate the injection sites, apply a cold pack over the injection area after the shot, and utilise Arnica gel after consulting your healthcare professional.
  • Ovarian stimulation and related discomfort: Enlargement of your ovaries during stimulation might often cause bloating, cramping, or feeling full. Relieve cramps with warm compresses, drink plenty of water to minimise bloating, and rest to prevent exacerbation of discomfort.
  • Egg retrieval procedure: Mild cramping and bloating may occur after the procedure while you are still feeling the effects of sedation. Rest and take over-the-counter pain medication, if recommended by your healthcare expert. If you experience severe pain, bleeding, or a fever, it’s important to seek medical attention right away.
  • Embryo transfer and post-procedure discomfort: The transfer itself is typically painless, though mild cramping or spotting may occur afterwards. Rest and use a heat pad for cramping. Spotting is considered normal and might resolve shortly.

Emotional pain management using IVF

Besides the physical pain, the emotional stress resulting from IVF can also be extreme. IVF is a procedure with several stressful phases and a number of uncertainties throughout the process. The emotional pain could, in some cases, further amplify the feeling of physical pain, implying that both must be addressed jointly.


  • Anxiety and stress: Uncertainty regarding IVF outcomes can increase anxiety and physical distress. Practice yoga, deep breathing, or mindfulness. It can reduce stress and anxiety by discussing with a counsellor or attending a support group.
  • Emotional exhaustion and mood swings: Hormonal changes may cause mood swings and emotional exhaustion. Take breaks, spend time for yourself, vent to your therapist or partner, and journal to work through your emotions.
  • The Two-Week Wait: The psychological tension of waiting for pregnancy test results can be overwhelming. Keep yourself occupied with hobbies or social activities. Be realistic and get emotional support from loved ones or professionals if needed.

While IVF might not be described as having an acute pain, it is a very complex medical intervention that can be punctuated with periods of bodily discomfort and psychological distress. Each phase, from the start with ovarian stimulation through the wait of two weeks, may present special challenges.

Most people find the symptoms manageable, with pain typically being mild to moderate and short-lived. To ease both physical and emotional discomfort, you can opt for specific measures, medical care, and self-care. By staying informed, paying attention to your body, and discussing any concerns with your healthcare expert, you can make the best decisions for yourself during this journey.


FAQs on Is IVF Really Painful? Everything You Need to Know About IVF Pain

  1. Is it safe to consume painkillers during IVF?
    It is safe to consume painkillers during your IVF treatment, but make sure to consult your healthcare professional before taking any strong medication.
  2. How to manage stress-related pain during IVF?
    There are several ways to take care of stress-related pain during IVF, such as being mindful, seeking counselling, engaging in exercise, and clear communication with your partner or healthcare professional.
Disclaimer: Medically approved by Dr Rohan Palshetkar, Consultant IVF Specialist, Bloom IVF, Palshetkar Patil Nursing Home, Opera House