Pregnancy and Underactive Thyroid: Here's All You Need to Know

Hypothyroidism is when your body produces less thyroid hormone. These hormones are crucial during pregnancy as they support various developmental processes in both the mother and the baby. When thyroid hormone levels drop below what is needed, it can cause complications for both mother and baby. Hence, monitoring thyroid function during pregnancy is vital.

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Hypothyroidism is common in pregnancy, and due to some of its symptoms, like fatigue, it can often go unnoticed. However, during your pregnancy, it is important to keep thyroid levels in check. This helps to ensure the proper well-being of you and your child.



Pregnancy and an underactive thyroid may lead to complications if not managed. It can contribute to symptoms like fatigue, weight changes, and menstrual irregularities, which might affect the chances of conception.

It also poses a risk of miscarriage. It can be helpful to stay in regular contact with your healthcare team and monitor both your hormone and thyroid levels throughout pregnancy.


Hypothyroidism: An Overview

Hypothyroidism is caused by an underactive thyroid, which means the thyroid doesn't produce enough hormones. This slows down your metabolism and can make you feel tired or cause weight gain, especially during pregnancy.


Though hypothyroidism is manageable, it is important to address it early to reduce the risk of complications such as preterm birth, developmental delays, and even stillbirth. Fortunately, with regular monitoring and appropriate treatment, most individuals with hypothyroidism can have a healthy pregnancy.

  • Role of thyroid hormone in pregnancy

Thyroid hormones are vital for the healthy development of the foetus, particularly in the early stages of pregnancy. In the first trimester, the mother’s thyroid hormones pass through the placenta to the foetus, supporting the early development of the brain and nervous system. This transfer of thyroid hormone is crucial because the foetal thyroid does not begin functioning until around the 12th week of pregnancy.

As the pregnancy progresses into the second trimester, the baby’s thyroid becomes functional, but maternal thyroid hormones continue to play an essential role in maintaining a healthy pregnancy.

Adequate levels of thyroid hormone support normal foetal growth, brain development, and metabolic functions. For the mother, thyroid hormones also help maintain metabolic stability and ensure that energy levels remain balanced throughout pregnancy.


Types of Hypothyroidism

There are several types of hypothyroidism, and recognising them is vital for proper diagnosis and treatment.

  • Primary hypothyroidism

The most common form of hypothyroidism, primary hypothyroidism occurs when the thyroid gland itself is unable to produce enough thyroid hormone.

This condition often leads to high levels of thyroid-stimulating hormone (TSH) as the body attempts to compensate for the low hormone levels. Primary hypothyroidism can be caused by conditions like Hashimoto’s disease, thyroid surgery, or radiation therapy.

  • Secondary hypothyroidism

In secondary hypothyroidism, the pituitary gland does not produce enough thyroid-stimulating hormone (TSH), which is necessary for stimulating the thyroid to produce its hormones. This rare condition can be caused by damage to the pituitary gland due to tumours or other issues.

  • Tertiary hypothyroidism

Tertiary hypothyroidism occurs when the hypothalamus in the brain fails to produce enough thyrotropin-releasing hormone (TRH).

This, in turn, prevents the pituitary gland from releasing sufficient TSH, thereby impacting thyroid function. This condition is also rare and often referred to as central hypothyroidism.

  • Subclinical hypothyroidism

Subclinical hypothyroidism is a mild thyroid condition where TSH (thyroid-stimulating hormone) levels are slightly elevated, but thyroid hormones T4 and T3 remain normal. This indicates the thyroid isn't producing enough hormones, though levels are still within an acceptable range.

During pregnancy, this condition should be monitored closely, as it can worsen. Treatment may be recommended if TSH levels rise significantly or if signs of autoimmune thyroid disease are present, such as TPO antibodies.

TPO antibodies are markers that can indicate an autoimmune attack on the thyroid gland, potentially worsening thyroid function. Regular monitoring and early intervention can help manage the condition and support both maternal and foetal health.


Symptoms of Hypothyroidism

Since there are different types of hypothyroidism, each of them can trigger different, yet subtle symptoms. These symptoms can often appear to be the same as other symptoms. Some of the common symptoms of hypothyroidism are as follows:

  • Low cold tolerance
  • Dry skin
  • Unexpected weight gain
  • Tiredness/lethargy
  • Slow heart rate
  • Depression
  • Thinning hair
If hypothyroidism is not treated during pregnancy, it may lead to complications such as high cholesterol and cardiovascular issues. In rare cases, it could also result in myxedema coma, which requires immediate medical attention.

Doctors recommend a blood test to rule out hypothyroidism, as some of its symptoms can be similar to those of a normal pregnancy. This helps ensure you receive the appropriate care and support.



Diagnosis of Hypothyroidism

Thyroid function testing includes Free T4, TSH and thyroid antibody tests to determine foetal and maternal well-being. Early diagnosis of hypothyroidism is important for pregnant women to prevent the risk of preterm birth, increased risk of miscarriage and foetal neurodevelopmental problems.

The usual trimester-specific range is as follows:

  • 1st Trimester (0–13 weeks): TSH: 0.1 to 2.5 mIU/L
  • 2nd Trimester (14–26 weeks): TSH: 0.2 to 3.0 mIU/L
  • 3rd Trimester (27–40 weeks): TSH: 0.3 to 3.0 mIU/L
These values may vary slightly depending on the laboratory standards or national clinical guidelines followed.


Treatment of Hypothyroidism

  • Primary Treatment

If you have hypothyroidism during pregnancy, you might need synthetic thyroid hormone. It’s important to take this only as prescribed by your doctor. The medicine helps keep your TSH levels healthy, with adjustments depending on the trimester.

  • Purpose of Medication

This medication replaces the thyroid hormone that your body may not produce enough of. It supports your health and may help reduce the risk of complications for both you and your baby. Your doctor monitors your levels and adjusts the dose as your pregnancy progresses.

  • Monitoring and Dosage

Healthcare professionals monitor TSH levels throughout pregnancy and adjust the dosage accordingly. This ensures that the thyroid hormone levels are sufficient for both the mother and the developing foetus.

  • Iodine Intake

During pregnancy, doctors recommend consuming a total of 250 mcg of iodine per day, including both dietary sources and supplements. However, it is best to avoid kelp or seaweed supplements, as they can cause excessive iodine intake, leading to thyroid dysfunction.

  • Medication Timing

Doctors typically recommend taking Levothyroxine on an empty stomach and at least four hours apart from iron or calcium supplements to ensure proper absorption.

It is recommended to undergo TPO antibody testing, especially if you have had subclinical hypothyroidism or are at risk for miscarriage.


How Does Thyroid Affect Pregnancy?

Low thyroid levels can affect women in numerous ways. Some of the ways it affects across different stages are as follows:

  • Pre-pregnancy

Hypothyroidism can prevent the egg from releasing during the ovulation phase, which makes conception difficult. It may also shorten the luteal phase, which is the second half of the menstrual cycle that begins after ovulation. A shorter luteal phase might not provide enough time for the uterine lining to fully develop, making it harder for a fertilised egg to implant and grow successfully.

Hypothyroidism may be linked to conditions such as ovarian cysts, elevated thyroid peroxidase antibodies, or lower basal body temperature. These factors might make it harder to conceive or could affect early pregnancy, but with proper management, many people go on to have healthy pregnancies.

If you have a family history of thyroid issues, it is extremely important to monitor them regularly. If it is not diagnosed promptly, there may be complications such as placental abruption and foetal neurodevelopmental issues.

It’s important to keep an eye out for the symptoms of thyroid issues, especially in early pregnancy. As soon as you notice any symptoms, it’s best to consult your doctor and get it treated. This prevents the risk from increasing later.

  • Pregnancy

If you are feeling very tired, having trouble concentrating, or gaining weight unexpectedly during pregnancy, it could be a sign of hypothyroidism. Let your doctor know as soon as possible so you can get the right treatment.

Your healthcare professional monitors the results to check that your hormones are at the appropriate level. Your body may also need higher hormone levels to support the baby.

Taking prenatal vitamins can be of great help. However, ensure that these have enough iron and calcium. If required, the doctor may also recommend hormone replacement therapy.

Uncontrolled symptoms of hypothyroidism can, however, be risky. This can have a severe negative impact on the growth and development of a baby's brain. Moreover, it also increases the risk of premature birth, maternal anaemia, miscarriage or an increase in maternal blood pressure.

  • Post-pregnancy

If you have autoimmune thyroid disease, there's a chance that you may have postpartum thyroiditis. The symptoms for this usually show within three or six months of giving birth and can last for a few weeks to months.

The symptoms of postpartum thyroiditis vary from woman to woman. However, it is extremely important to note how your body is reacting in the early stages. If you have hypothyroidism, it can also affect your body's capacity to produce milk.

Therefore, in that case, you might have to undergo proper hormone replacement therapy to solve the problem. Around 15-20% of women who have postpartum thyroiditis end up developing permanent hypothyroidism.


Possible Signs of Thyroid Dysfunction During Pregnancy

If you are concerned about thyroid function during pregnancy, being aware of certain changes in your body may be helpful. Some signs that could suggest an imbalance include:

  • Weight gain
  • Extreme fatigue
  • Skin and hair colour change
  • Hoarse voice
  • Palpitations


What Causes Thyroid Diseases During Pregnancy?

Hashimoto's Disease is a common condition that can affect thyroid function during pregnancy. This autoimmune disease causes the immune system to attack the thyroid gland, which can reduce thyroid hormone production. As a result, symptoms such as joint stiffness, constipation, sensitivity to cold, and muscle weakness may occur during pregnancy.


Maintaining Thyroid Health During Pregnancy

Whether you have a pre-existing thyroid condition or not, you need to be mindful of your thyroid health during pregnancy. The arising complications can make it difficult for your child. Therefore, here are a few tips on maintaining thyroid health during pregnancy:

  • Regular prenatal checkups

Never miss your checkups with healthcare professionals. During prenatal visits, they check your thyroid levels and monitor for any abnormalities. If any issues are found, early detection helps prevent complications later in pregnancy.

  • Proper exercise

Apart from a healthy and nutritious diet, it is advisable to take care of your health with some pregnancy-friendly exercises. Engage in moderate, pregnancy-safe physical activity, as your healthcare expert may advise. Support your well-being with balanced nutrition, including foods like seafood, dairy products, and iodised salt to help maintain healthy iodine levels.

  • Avoid excessive iodine intake

While you're consuming iodised salt to maintain your thyroid health, make sure that you're not consuming an excess of it. Too much iodine can be harmful to the body. If your healthcare professionals haven't recommended it, it’s best to avoid these iodine supplements.

  • Stress management

Chronic stress can affect your thyroid function, so it’s important to manage stress during pregnancy. Try techniques like yoga, meditation, and deep breathing to help keep stress under control.


Risks of Untreated Hypothyroidism

If proper diagnosis is done on time, a lot of women can have a healthy pregnancy despite hypothyroidism. However, if hypothyroidism isn't treated on time, it can cause a lot of other complications for the mother, such as the following:


  • Preeclampsia
  • Anaemia
  • Miscarriage
  • Placental abruption
  • Postpartum haemorrhage

Hypothyroidism affects the child’s health in numerous ways, such as the following:

  • Preterm birth
  • Stillbirth
  • Developmental delays
  • Congenital hypothyroidism
  • Low birth weight

Postpartum Considerations

After you give birth, your thyroid medication may need to return to your pre-pregnancy dosage. It's important to check your thyroid levels to ensure the medication remains right for you. Factors such as the type of thyroid condition, its severity, and whether you're breastfeeding can all influence your dosage needs.

Postpartum thyroiditis can occur after childbirth, especially if you have a history of Type 1 diabetes, previous thyroiditis, or positive thyroid peroxidase antibodies (TPOAb). If this applies to you, it’s important to consult with your healthcare professional. Regular screening of your TSH levels helps monitor your thyroid function.

If you have a history of postpartum thyroiditis, ongoing follow-up is generally recommended to help manage your thyroid health in the long term. It’s best to speak to your healthcare expert for personalised advice based on your specific health history.

  • Impact of hypothyroidism on breastfeeding

Some people with hypothyroidism may notice changes in their milk supply. In such cases, adjusting thyroid medication might help support lactation. Levothyroxine is often considered safe to use while breastfeeding, especially when managing thyroid levels. It may be helpful to speak with a healthcare professional to find a suitable approach for maintaining thyroid health during this time.

  • When to seek medical advice?

Poorly managed thyroid can lead to different symptoms like mood swings, intolerance and weight change. If you experience sudden vision changes or eye pain, contact a healthcare professional immediately.

If you notice any symptoms, it’s important to let your healthcare professional know. They can carry out tests and create the right treatment plan for you. Keeping track of changes in your body and getting them checked early is important for both your health and your baby’s.

With appropriate monitoring and treatment, individuals with hypothyroidism can experience a healthy pregnancy and deliver a healthy baby. Regular thyroid function tests, consistent follow-up with healthcare professionals, and effective management of thyroid hormone levels are essential.

Maintaining optimal thyroid health during pregnancy is vital not only for your overall well-being and energy levels but also for the healthy development of your baby. It is important to consult with your healthcare expert for personalised guidance and recommendations.

FAQs

  1. Can an underactive thyroid harm pregnancy?
    Yes, an underactive thyroid can harm pregnancy. If not treated at the right time, it can increase the risk of pregnancy and preterm birth.
  2. Can an underactive thyroid make it hard to get pregnant?
    Yes, an underactive thyroid can make it difficult to get pregnant. It is advisable to consult your healthcare professional.
Disclaimer: Medically approved by Dr Rashmi N, Consultant - Obstetrician & Gynaecologist, Motherhood Hospitals, Kothanur, Bangalore.