Why Too Much Iron Can Be Harmful in Pregnancy

Iron is usually seen as your ally in pregnancy, but what happens when your body gets more than it needs? Iron overload is a condition where excess iron builds up in organs like the liver, heart, and pancreas. Over time, this can affect how your body works and may even slow down your baby’s growth.

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When you’re pregnant, you hear a lot about iron deficiency. Doctors, books, and articles all stress how important it is to get enough iron for you and your baby. But what if the problem isn’t too little iron, but too much? Iron overload in pregnancy is not something people usually talk about, yet it can be just as important to understand. Your body needs iron to make blood and carry oxygen, but there’s a fine line between what’s helpful and what’s harmful. Crossing that line can bring challenges you might not expect.

Why is Iron Important During Pregnancy?

Iron is important for your body during pregnancy because it supports the increased blood volume needed for you and your growing baby. It combines with proteins to create haemoglobin, which carries oxygen through your blood and helps prevent anaemia. Your body’s iron needs increase during pregnancy due to this increased demand, and food alone often can’t meet them. That’s why doctors may recommend iron supplements.

What Causes Iron Overload in Pregnancy?

Iron overload happens when there’s too much iron in your body, either from supplements, diet, or other conditions. Take a look at the main reasons why this might happen:
  • Excessive iron supplements in pregnancy: Taking iron supplements without a doctor’s guidance or beyond what’s needed can lead to a buildup.
  • Genetic conditions: Hereditary hemochromatosis makes your body absorb more iron than it needs from food or supplements. Although this condition is less common in India.
  • Underlying health issues: Conditions like liver disorders or inefficient red blood cell production can cause secondary hemochromatosis, leading to excess iron storage.
  • Neonatal hemochromatosis: This condition affects the foetus or newborn when the mother’s immune system attacks the baby’s liver, causing iron to build up. It’s not genetic, but it can be severe.

Risks of Iron Overload During Pregnancy

Iron overload can cause serious issues for you and your baby:

For You

  • Liver and spleen strain: Excess iron can build up in these organs and may lead to inflammation or even liver failure over time.
  • Gestational diabetes: High iron levels can make your body resist insulin, raising your risk of developing diabetes during pregnancy.
  • Cardiovascular issues: Long-term iron buildup can contribute to heart problems or even stroke.
  • Oxidative stress: Excess iron creates free radicals that can damage cells and cause inflammation.

For Your Baby

  • Low birth weight: When iron levels get too high, it can interfere with how blood and oxygen reach your baby.
  • Preterm birth: Iron overload is linked to a higher chance of early delivery.
  • Foetal death: In severe cases, iron overload can lead to tragic outcomes like stillbirth, especially if maternal toxicity is high.

Iron Overload Symptoms During Pregnancy

This condition can be difficult to notice since the symptoms can feel like normal pregnancy changes. But if you notice these signs, it’s worth checking with your doctor:
  • Digestive issues: Nausea, vomiting, abdominal pain, diarrhoea, or constipation that feels unusual or severe.
  • Fatigue and weakness: Feeling extremely tired even after rest.
  • Joint pain: Aching in your knees, wrists, or other joints without any clear reason.
  • Skin changes: A bronze or grey tint to your skin, which isn’t due to sun exposure.
  • Breathing or heart issues: Shortness of breath, rapid breathing, or a fast heartbeat.

How is Iron Overload Diagnosed?

If your doctor suspects iron overload, they’ll use specific tests to confirm it:
  • Serum ferritin test: This checks your stored iron levels. High levels can signal overload, though inflammation might affect results.
  • Transferrin saturation test: This measures how much iron is bound to the protein that carries it in your blood. A value above 45 per cent is considered high.
  • Liver function tests: These look for signs of liver stress or damage, which can happen with iron buildup.

Managing Iron Overload During Pregnancy

Your doctor will act quickly to reduce your iron levels safely if you’re diagnosed with iron overload:

1. Stop Iron Supplements

If you’re taking iron supplements in pregnancy, your doctor will likely ask you to stop immediately to prevent further buildup.

2. Dietary Changes

  • Eat high-fibre foods to reduce iron absorption.
  • Include fruits and vegetables rich in vitamin C, but avoid taking vitamin C supplements with iron, as they increase absorption.
  • Try diuretic foods to help your body flush out excess iron.
  • Limit iron-rich foods.

3. Medical Treatments

  • In severe cases, your doctor might suggest iron chelation therapy (use of special medicines called chelators) to remove excess iron. There is limited data on how safe it is for the baby, so doctors use it with caution when needed.
  • Stomach flushing might be done in extreme cases of overdose.

4. Monitoring

Regular blood tests (every four weeks or so) will track your iron levels to make sure they’re coming down without affecting your pregnancy.

Preventing Iron Overload

Prevention is always better than treatment, especially during pregnancy. These are some steps to avoid iron overload:
  • Don’t start iron supplements on your own. Your doctor will check your iron levels first to see if you need them.
  • Get iron from foods rather than relying heavily on iron supplements in pregnancy.
  • If you need both iron and calcium, take them at different times of the day.
  • If prescribed, take iron on an empty stomach with water, ideally 1 hour before or 2 hours after meals. This can improve absorption without overloading.
  • Routine prenatal visits with blood tests will catch any spikes in iron levels early, so your doctor can adjust your plan.
If you’re worried about iron overload or notice symptoms like unusual fatigue or abdominal pain, reach out to your doctor. They can run tests and guide you on the next steps to keep you and your baby safe.
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FAQs on Why Too Much Iron Can Be Harmful in Pregnancy

  1. When to stop taking iron tablets in pregnancy?
    You should only stop iron tablets if your doctor advises you to. Sometimes, blood tests show that your iron levels are already high. In that case, your doctor may reduce the dose or stop them to avoid overload.
  2. What happens if you have too much iron in pregnancy?
    Too much iron can build up in your body and affect organs like the liver, heart, and pancreas. It may also raise the risk of gestational diabetes or high blood pressure.
Disclaimer: Medically approved by Dr Arun Jadhav, Obstetrician & Gynecologist, Ichalkaranji